abstract：BACKGROUND:A feature often seen in adolescent patients with cancer is a lengthy symptom interval, especially in comparison with children. It has been suggested that inadequate awareness of cancer risk among adolescents may play an important role in this study. METHODS:The Società Italiana Adolescenti con Malattie Onco...

journal_title：Pediatric blood & cancer

authors： Magni C,Segrè C,Finzi C,Veneroni L,Clerici CA,Massimino M,Casanova M,Martinella V,Chiaravalli S,Ricci A,Biondi A,Ferrari A

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Children with sickle cell disease (SCD) and moyamoya may benefit from indirect cerebral revascularization surgery in addition to chronic blood transfusion therapy for infarct prevention. We sought to compare overt and silent infarct recurrence rates in children with SCD undergoing revascularization. METHODS...

journal_title：Pediatric blood & cancer

authors： Hall EM,Leonard J,Smith JL,Guilliams KP,Binkley M,Fallon RJ,Hulbert ML

更新日期：2016-08-01 00:00:00

abstract：:We evaluated the in vitro glucocorticoid (GC) responsiveness of 117 pediatric acute myeloid leukemia cells by considering GC resistance, GC-induced proliferation, and GC-induced differentiation. None of the samples was highly GC sensitive, and only 15% were intermediately sensitive. GC-induced differentiation was not ...

journal_title：Pediatric blood & cancer

authors： Klein K,Haarman EG,de Haas V,Zwaan ChM,Creutzig U,Kaspers GL

更新日期：2016-08-01 00:00:00

abstract：:Squamous cell carcinoma of the anal canal in children is rare. To date, the etiology and outcome of this condition have been not fully understood. Here, we report an 11-year-old child with anal canal cancer who had concomitant disorders of sex development. Radiotherapy followed by salvage surgery achieved disease-free...

journal_title：Pediatric blood & cancer

authors： Watanabe T,Horikawa R,Masaki H,Yoshioka T,Matsumoto K,Kanamori Y

更新日期：2016-07-01 00:00:00

abstract：:A newborn with unresectable kaposiform hemangioendothelioma associated with Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second-line treatment with propranolol at a dose of 2 mg/kg/day, starting at 2 months of life and continued for 13 months. There was only slight reduction in tum...

journal_title：Pediatric blood & cancer

authors： Filippi L,Tamburini A,Berti E,Perrone A,Defilippi C,Favre C,Calvani M,Della Bona ML,la Marca G,Donzelli G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Complications in pediatric cancer patients after a gastrostomy (GT) placement have not been widely investigated. We aimed to evaluate the complication rate and nature of complications in this specific population. PROCEDURE:Medical records of pediatric cancer patients having a GT placed at our institution fr...

journal_title：Pediatric blood & cancer

authors： Fernandez-Pineda I,Sandoval JA,Jones RM,Boateng N,Wu J,Rao BN,Davidoff AM,Shochat SJ

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Stroke is a severe complication of sickle cell anemia (SCA). The role of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the development of stroke in children with SCA is controversial. PROCEDURE:The aim of this study was to investigate the association of clinical ischemic stroke, high-risk transcran...

journal_title：Pediatric blood & cancer

authors： Belisário AR,Rodrigues Sales R,Evelin Toledo N,Velloso-Rodrigues C,Maria Silva C,Borato Viana M

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Population-based evidence suggests that lower socioeconomic status (SES) negatively impacts the overall survival (OS) of children with leukemia; however, the relationships between SES and treatment-related mortality, relapse, and timing of relapse remain unclear. PROCEDURE:We examined OS, event-free surviva...

journal_title：Pediatric blood & cancer

authors： Bona K,Blonquist TM,Neuberg DS,Silverman LB,Wolfe J

更新日期：2016-06-01 00:00:00

abstract：:Minimal residual disease (MRD) is an independent predictor of relapse risk in children with leukemia and is widely used for risk-adapted treatment. This article summarizes current evidence supporting the use of MRD, including clinical significance, current international clinical practice, impact statement, and recomme...

journal_title：Pediatric blood & cancer

authors： Athale UH,Gibson PJ,Bradley NM,Malkin DM,Hitzler J,POGO MRD Working Group.

更新日期：2016-06-01 00:00:00

abstract：:While encapsulated bacterial agents, particularly Streptococcus pneumoniae, are recognized as important microbes that are associated with serious illness in hosts with sickle cell disease (SCD), multiple pathogens are implicated in infectious manifestations of SCD. Variations in clinical practice have been an obstacle...

journal_title：Pediatric blood & cancer

authors： Obaro SK,Iroh Tam PY

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The Children's Oncology Group (COG) publishes consensus guidelines with screening recommendations for early identification of treatment-related morbidities among childhood cancer survivors. We sought to estimate the yield of recommended yearly urinalysis screening for genitourinary complications as per Versi...

journal_title：Pediatric blood & cancer

authors： Ramirez MD,Mertens AC,Esiashvili N,Meacham LR,Wasilewski-Masker K

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Treatment abandonment (TxA) is a primary cause of therapy failure in children with cancer in low-/middle-income countries. We explored the absence of social support network (SSN), among other predictive factors, and TxA in children with cancer in Cali, Colombia. PROCEDURE:In this prospective cohort study, w...

journal_title：Pediatric blood & cancer

authors： Ospina-Romero M,Portilla CA,Bravo LE,Ramirez O,VIGICANCER working group.

更新日期：2016-05-01 00:00:00

abstract：:We describe a child with dyserythropoietic anemia, thrombocytosis, functional platelet defect, and megakaryocyte dysplasia. We show that (i) this constellation of hematopoietic abnormalities was due to a germline mutation within the 5' untranslated region (5'UTR) of globin transcription factor 1 (GATA1); (ii) the muta...

journal_title：Pediatric blood & cancer

authors： Zucker J,Temm C,Czader M,Nalepa G

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Primary mediastinal germ cell tumors (GCTs) are rare in children and still represent a challenge for both adult and pediatric oncologists because of their worse outcome compared to their gonadal counterpart. PROCEDURE:Prospectively collected data concerning patients enrolled in the Italian Association of Pe...

journal_title：Pediatric blood & cancer

authors： De Pasquale MD,Crocoli A,Conte M,Indolfi P,D'Angelo P,Boldrini R,Terenziani M,Inserra A

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Studies have shown that children with cancer globally lack access to palliative care. Little is known regarding physicians' perceptions of palliative care, treatment access, and self-reported competence in providing palliative care. PROCEDURE:Members of the Global Neuroblastoma Network (online tumor board) ...

journal_title：Pediatric blood & cancer

authors： Balkin EM,Thompson D,Colson KE,Lam CG,Matthay KK

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Right hemicolectomy (RHC) in patients with neuroendocrine tumors (NET) of the appendix has been advocated for tumors more than 2 cm, or with mesoappendix/vessel invasion, or with raised mitotic activity. No study demonstrated prolonged survival with RHC over appendectomy alone. The aim of this study was to c...

journal_title：Pediatric blood & cancer

authors： de Lambert G,Lardy H,Martelli H,Orbach D,Gauthier F,Guérin F

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:We sought to assess patterns of failure in pediatric patients with intracranial germ cell tumors (GCT) treated with intensity-modulated radiation therapy with dose painting (DP-IMRT). PROCEDURE:Between July 2007 and October 2013, 11 patients with localized GCT-five germinomas and six nongerminoma GCT (NGGCT...

journal_title：Pediatric blood & cancer

authors： Yang JC,Terezakis SA,Dunkel IJ,Gilheeney SW,Wolden SL

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:In malaria-endemic countries in West Africa, sickle cell disease (SCD) contributes to childhood mortality. Historically, Liberia had regions wherein hemoglobin S and beta-thalassemia trait were mutually exclusive. Data on hemoglobinopathies in the Monrovia, the capital, are outdated and do not reflect urban ...

journal_title：Pediatric blood & cancer

authors： Tubman VN,Marshall R,Jallah W,Guo D,Ma C,Ohene-Frempong K,London WB,Heeney MM

更新日期：2016-04-01 00:00:00

abstract：:Limited high-quality evidence supports the management of iron deficiency anemia (IDA). To assess our institutional performance in this area, we retrospectively reviewed IDA treatment practices in 195 consecutive children referred to our center from 2006 to mid-2010. The majority of children were ≤4 years old (64%) and...

journal_title：Pediatric blood & cancer

authors： Powers JM,Daniel CL,McCavit TL,Buchanan GR

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:(131) I-metaiodobenzylguanidine ((131) I-MIBG) is a targeted radiopharmaceutical for patients with neuroblastoma. Despite its tumor-specific uptake, the treatment with (131) I-MIBG results in whole-body radiation exposure. Our aim was to correlate whole-body radiation dose (WBD) from (131) I-MIBG with tumor ...

journal_title：Pediatric blood & cancer

authors： Trieu M,DuBois SG,Pon E,Nardo L,Hawkins RA,Marachelian A,Twist CJ,Park JR,Matthay KK

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Langerhans cell histiocytosis (LCH) is a rare disease, frequently affecting young children. PROCEDURE:We performed a retrospective study in patients younger than 16 years old manifesting with skin symptoms, and documented their different cutaneous lesions and systemic symptoms. We compared subgroups of chil...

journal_title：Pediatric blood & cancer

authors： Morren MA,Vanden Broecke K,Vangeebergen L,Sillevis-Smitt JH,Van Den Berghe P,Hauben E,Jacobs S,Van Gool SW

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Patient transition readiness self-assessment tools and investigation into patient and parent perceptions of the transition process from pediatric to adult care models have informed recognition of gaps in care, particularly for those with chronic disease. Implementation of a longitudinal transition process wi...

journal_title：Pediatric blood & cancer

authors： Croteau SE,Padula M,Quint K,D'Angelo L,Neufeld EJ

更新日期：2016-03-01 00:00:00

abstract：:Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in...

journal_title：Pediatric blood & cancer

authors： Hagelstrom RT,Ford J,Reiser GM,Nelson M,Pickering DL,Althof PA,Sanger WG,Coccia PF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Diamond-Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome. The mainstays of treatment involve chronic red cell transfusions, long-term glucocorticoid therapy, and stem cell transplantation. Systematic data concerning endocrine function in DBA are limited. We studied patients in the DBA R...

journal_title：Pediatric blood & cancer

authors： Lahoti A,Harris YT,Speiser PW,Atsidaftos E,Lipton JM,Vlachos A

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The use of carboplatin for the treatment of pediatric low grade gliomas (PLGG) is often limited by the development of carboplatin hypersensitivity. Reported rates of carboplatin hypersensitivity reactions vary between 6% and 32% in these patients. Here we report the frequency of carboplatin hypersensitivity ...

journal_title：Pediatric blood & cancer

authors： Dodgshun AJ,Hansford JR,Cole T,Choo S,Sullivan MJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Fever and neutropenia (F&N) is a pediatric oncology emergency due to the risk of disseminated infection. Quality improvement (QI) efforts to improve time to antibiotics for F&N in the emergency department have been documented, but the issue has not been studied in the established inpatient setting. PROCEDUR...

journal_title：Pediatric blood & cancer

authors： Green AL,Yi J,Bezler N,Pikman Y,Tubman VN,Obeng EA,O'Neil T,Mersereau R,Morrissey L,Billett AL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Although chemotherapy has improved outcome of osteosarcoma, 30-40% of patients succumb to this disease. Survivors experience substantial morbidity and mortality from anthracycline-induced cardiotoxicity. We hypothesized that the cardioprotectant dexrazoxane would (i) support escalation of the cumulative doxo...

journal_title：Pediatric blood & cancer

authors： Schwartz CL,Wexler LH,Krailo MD,Teot LA,Devidas M,Steinherz LJ,Goorin AM,Gebhardt MC,Healey JH,Sato JK,Meyers PA,Grier HE,Bernstein ML,Lipshultz SE

更新日期：2016-01-01 00:00:00

abstract：:Severe congenital neutropenia (SCN) is a bone marrow failure disease with an autosomal dominant inheritance from mutations in ELANE. Here, we report a 7-week-old Korean male with SCN. His elder sister died from pneumonia at 2 years. Direct sequencing of ELANE in the proband identified a heterozygous novel frameshift m...

journal_title：Pediatric blood & cancer

authors： Kim HJ,Song MJ,Lee KO,Kim SH,Kim HJ

更新日期：2015-12-01 00:00:00

abstract：:Acute gastrointestinal graft-versus-host disease (GVHD) refractory to first-line treatment with systemic corticosteroids results in increased morbidity and potential mortality. We retrospectively assessed the feasibility and efficacy of catheter-directed intra-arterial platelet infusion (IAPI) in two pediatric patient...

journal_title：Pediatric blood & cancer

authors： Kably IM,Ziga ED,Andreansky M

更新日期：2015-12-01 00:00:00

abstract：:Family financial hardship has emerged as a burden of pediatric cancer treatment with negative implications for family well-being. As part of an extensive project to create evidence-based standards for the psychosocial care of children with cancer, we performed a literature review of pediatric cancer-associated financi...

journal_title：Pediatric blood & cancer

authors： Pelletier W,Bona K

更新日期：2015-12-01 00:00:00

abstract：:As part of a larger effort to create standards for psychosocial care of children with cancer, we document consensus and evidence-based data on interprofessional communication, documentation, and training for professionals providing psycho-oncology services. Six databases were searched. Sixty-five articles and six guid...

journal_title：Pediatric blood & cancer

authors： Patenaude AF,Pelletier W,Bingen K

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Follicular variant of papillary thyroid carcinoma (FVPTC) has been shown to be an intermediate entity between papillary (PTC) and follicular/Hurtle cell (FTC) thyroid carcinoma in adults. However, the tumor characteristics and prognosis of FVPTCs has not been studied in the pediatric population and is the fo...

journal_title：Pediatric blood & cancer

authors： Lerner J,Goldfarb M

更新日期：2015-11-01 00:00:00

abstract：:Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15-year-old female with multiple recurrent AFOS. She responded to chemothera...

journal_title：Pediatric blood & cancer

authors： Gatz SA,Thway K,Mandeville H,Kerawala C,MacVicar D,Chisholm J

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Children with sickle cell disease (SCD) are at increased risk of death from invasive bacterial infections. Emergent evaluation of fever allows early treatment of potentially fatal infections. Limited data exist regarding caregiver adherence to physician recommendations of prompt medical evaluation of fever i...

journal_title：Pediatric blood & cancer

authors： Schultz CL,Tchume-Johnson T,Schapira MM,Bellamy S,Smith-Whitley K,Ellison A

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:About one-third of patients with rhabdomyosarcoma relapse despite appropriate treatment and experience a poor outcome. Little meaningful improvement in the outcome of this disease has been observed over the last 30 years. There is no clear international recommendation concerning the use of salvage chemotherapy ...

journal_title：Pediatric blood & cancer

authors： Winter S,Fasola S,Brisse H,Mosseri V,Orbach D

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The high cost, coupled with the need for continuous infusion, renders Desferrioxamine (DFO), a non-feasible option for iron-chelation in a large majority of patients with β-thalassemia major in developing countries. Monotherapy with deferiprone (DFP) or deferasirox (DFX) may not always attain optimal control...

journal_title：Pediatric blood & cancer

authors： Totadri S,Bansal D,Bhatia P,Attri SV,Trehan A,Marwaha RK

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Sickle cell anaemia (SCA) is the leading genetic disorder in Nigeria. Elevated velocities ≥170 cm/sec occur in about a third of Nigerian children with SCA. Chronic blood transfusion for stroke prevention is faced with a myriad of challenges in our practice. OBJECTIVES:To evaluate the effectiveness of hydrox...

journal_title：Pediatric blood & cancer

authors： Lagunju I,Brown BJ,Sodeinde O

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Treatment intensification was considered a suitable strategy to increase the cure rate of lymphoblastic lymphoma (LBL) in children. PROCEDURE:The AIEOP LNH-97 trial was run between 1997 and 2007 for newly diagnosed LBL in patients aged less than 18 years. Treatment schedule was based on the previous, LSA2-L...

journal_title：Pediatric blood & cancer

authors： Pillon M,Aricò M,Mussolin L,Carraro E,Conter V,Sala A,Buffardi S,Garaventa A,D'Angelo P,Lo Nigro L,Santoro N,Piglione M,Lombardi A,Porta F,Cesaro S,Moleti ML,Casale F,Mura R,d'Amore ES,Basso G,Rosolen A

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Many pediatric oncology patients undergoing hematopoietic stem cell transplantation (HSCT) require nutritional support (NS) because of their inability to consume adequate caloric intake enough calories orally. Although NS can be provided either enteraly (EN) or parenteraly (PN), EN is the preferred method of...

journal_title：Pediatric blood & cancer

authors： Williams-Hooker R,Adams M,Havrilla DA,Leung W,Roach RR,Mosby TT

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Childhood cancer is relatively rare and tends to present specific age distribution, as a prognostic factor for some of these diseases. Information on how young age affects prognosis, response to chemotherapy, and local control options in children versus AYA with osteosarcoma (OST) is minimal. METHODS:In ord...

journal_title：Pediatric blood & cancer

authors： Eleutério SJ,Senerchia AA,Almeida MT,Da Costa CM,Lustosa D,Calheiros LM,Barreto JH,Brunetto AL,Macedo CR,Petrilli AS

更新日期：2015-07-01 00:00:00